Welcome to Python Anesthesia Simulator’s documentation!

The Python Anesthesia Simulator (PAS) models the effect of drugs on physiological variables during total intravenous anesthesia. It is particularly dedicated to the control community, to be used as a benchmark for the design of multidrug controllers. The available drugs are Propofol, Remifentanil, and Norepinephrine, the outputs are the Bispectral index (BIS), Mean Arterial Pressure (MAP), Cardiac Output (CO), and Tolerance of Laryngoscopy (TOL). PAS includes different well-known models along with their uncertainties to simulate inter-patient variability. Blood loss can also be simulated to assess the controller’s performance in a shock scenario. Finally, PAS includes standard disturbance profiles and metric computation to facilitate the evaluation of the controller’s performances. This web page provides a brief overview of the simulator and its capabilities. For more details, please refer to the following paper: https://joss.theoj.org/papers/10.21105/joss.05480. If you are using PAS for your research, please cite the previous paper.

Contents:

• Introduction
  • Installation
  • Statement of need
• Simulator module
  • Patient
• PK models module
  • CompartmentModel
• PD models module
  • BIS_model
  • Hemo_PD_model
  • TOL_model
  • fsig()
• Disturbances module
  • compute_disturbances()
• Metrics module
  • compute_control_metrics()
  • intergal_absolut_error()
  • new_metrics_induction()
  • new_metrics_maintenance()
• TCI controller module
  • TCIController
• Examples
  • 1. Blood loss simulation
  • 2. VitalDB model check
  • 3. PID design pipeline
  • 4. TCI simulation