Welcome to Python Anesthesia Simulator’s documentation!

The Python Anesthesia Simulator (PAS) models the effect of drugs on physiological variables during total intravenous anesthesia. It is particularly dedicated to the control community, to be used as a benchmark for the design of multidrug controllers. The available drugs are Propofol, Remifentanil, and Norepinephrine, the outputs are the Bispectral index (BIS), Mean Arterial Pressure (MAP), Cardiac Output (CO), and Tolerance of Laryngoscopy (TOL). PAS includes different well-known models along with their uncertainties to simulate inter-patient variability. Blood loss can also be simulated to assess the controller’s performance in a shock scenario. Finally, PAS includes standard disturbance profiles and metric computation to facilitate the evaluation of the controller’s performances. This document provides the statement of need and the documentation to use the package. Some examples are also available in the package folder to better understand how to use it.

Contents:

• Introduction
  • Installation
  • Statement of need
• Simulator module
  • Patient
• PK models module
  • CompartmentModel
• PD models module
  • BIS_model
  • Hemo_PD_model
  • TOL_model
  • fsig()
• Disturbances module
  • compute_disturbances()
• Metrics module
  • compute_control_metrics()
• Examples
  • 1. Blood loss simulation
  • 2. VitalDB model check
  • 3. PID design pipeline